Research Articles:
2009
33. “Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif” J. Sutharsan, M. Dakanali, C.C. Capule, M.A. Haidekker, J. Yang,* and E. Theodorakis* ChemMedChem 2009, accepted
32. “A Semi-Synthetic Ion Channel Platform for Detection of Phosphatase and Protease Activity” M.X. Macrae, S. Blake, X. Jiang, R. Capone, D. J. Estes, M. Mayer,* and J. Yang* ACS Nano 2009, in press [Link]
31. “Gramicidin Pores Report the Activity of Membrane-Active Enzymes” S. Majd, E.C. Yusko, A.D. Macbriar, J. Yang,* and M. Mayer* J. Am. Chem. Soc. 2009, 131, 16119-16126 [Link]
30. “Reactive Derivatives of Gramicidin Enable Light- and Ion-Modulated Ion Channels” M.X. Macrae, S. Blake, T. Mayer, M. Mayer,* and J. Yang* Proc. SPIE 2009, 7397, 739709-01-739709-13 [Link]
29. “A Non-chromatographic Method for the Purification of a Bivalently Active Monoclonal IgG Antibody from Biological Fluids” B. Bilgicer, S. Thomas, B. Shaw, G. Kaufman, V. Krishnamurthy, L. Estroff, J. Yang, and G.M. Whitesides* J. Am. Chem. Soc. 2009, 131, 9361-9367 [Link]
28. “Amyloid-beta Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy” R. Capone, P. Prangkio, A. M. Sauer, M. R. Bautista, R. S. Turner, J. Yang,* and M. Mayer* Neurotox. Res. 2009, 16, 1-13 [Link] also see UCSD press release
2008
27. “Chemically Reactive Derivatives of Gramicidin A for Developing Ion Channel-Based Nanoprobes” S. Blake, R. Capone, M. Mayer,* and J. Yang* Bioconjugate Chem. 2008, 19, 1614-1624 [Link]
26. “Assay to Screen for Molecules that Associate with Alzheimer’s Related b-Amyloid Fibrils” P. Inbar, M. R. Bautista, S. A. Takayama, and J. Yang* Anal. Chem., 2008, 80, 3502-3506 [Link]
25. “Using Ion Channel-Forming Peptides to Quantify Protein-Ligand Interactions” M. Mayer, V. Semetey, I. Gitlin, J. Yang, and G.M. Whitesides* J. Am. Chem. Soc., 2008, 130, 1453-1465 [Link]
2007
24. “Designing Nanosensors based on Charged Derivatives of Gramicidin A” R. Capone, S. Blake, M. R. Restrepo, J. Yang,* and M. Mayer* J. Am. Chem. Soc., 2007, 129, 9737-9745 [Link]
23. “Acidic Hydrolysis of N-ethoxybenzylimidazoles: Potential Applications as pH-Sensitive Linkers for Drug Delivery” S.D. Kong, A. Luong, G. Manorek, S.B. Howell, and J. Yang* Bioconjugate Chem., 2007, 18, 293-296 [Link]
2006
22. “Oligo(ethylene glycol) Derivatives of Thioflavin T as Inhibitors of Protein-Amyloid Interactions” P. Inbar, C. Q. Li, S. A. Takayama, M. R. Bautista, J. Yang* ChemBioChem, 2006, 7, 1563-1566 [Link]
21. “Monitoring Chemical Reaction Using Ion Channel-Forming Peptides” S. Blake, T. Mayer, M. Mayer,* and J. Yang* ChemBioChem, 2006, 7(3), 433-435 [Link]
20. “Inhibiting Protein-Amyloid Interactions with Small Molecules: A Surface Chemistry Approach” P. Inbar and J. Yang* Bioorg. Med. Chem. Lett., 2006, 16, 1076-1079 [Link]
2005
19. “A Bacterial Printing Press that Regenerates its Ink: Contact Printing Bacteria Using Hydrogel Stamps” D.B. Weibel, A. Lee, M. Mayer, S.F. Brady, J. Yang, W. DiLuzio, and G.M. Whitesides* Langmuir, 2005, 21, 6436-6442 [Link]
18. “Eliminating Positive Charges on the Surface of Carbonic Anhydrase has no Significant Influence on Folding from Sodium Dodecyl Sulfate” K. L. Guidiksen, I. Gitlin, J. Yang, A. R. Urbach, and G. M. Whitesides* J. Am. Chem. Soc., 2005, 127, 4707-4714 [Link]
2004
17. “The influence of the Zn(II) cofactor on the refolding of Bovine Carbonic Anhydrase after Denaturation with SDS” K. L. Guidiksen, A. R. Urbach, I. Gitlin, J. Yang, J. A. Vazquez, C. E. Costello, and G. M. Whitesides* Anal. Chem., 2004, 76, 7151-7161 [Link]
16. “Self-Assembled Aggregates of IgGs as Templates for the Growth of Clusters of Gold Nanoparticles” J. Yang,* M. Mayer, J.K. Kriebel, P. Parstecki, and G.M. Whitesides* Angew. Chem. Int. Ed., 2004, 43, 1555-1558 [Link]
15. “Micropatterned Agarose Gels for Stamping Arrays of Proteins and Gradients of Proteins” M. Mayer, J. Yang, I. Gitlin, D. Gracias, and G.M. Whitesides* Proteomics, 2004, 4, 2366-2376 [Link]
2003
14. “Synthesis of Monodisperse Polymers from Proteins” J. Yang, I. Gitlin, V.M. Krishnamurthy, J.A. Vazquez, C.E. Costello, and G.M. Whitesides* J. Am. Chem. Soc., 2003, 125, 12392-12393 [Link]
2002
13. “The Redox Properties of Cytochrome c Adsorbed on Self-Assembled Monolayers: A probe for Protein Conformation and Orientation” X. Chen, R. Ferrigno, J. Yang, and G. M. Whitesides* Langmuir, 2002, 18, 7009-7015 [Link]
12. “Massively Parallel Adhesion and Reactivity Measurements Using a Simple and Inexpensive Magnetic Tweezers” F. Assi, R. Jenks, J. Yang, C. Love, and M. Prentiss* J. Appl. Phys., 2002, 92, 5584-5586 [Link]
11. “Fabrication of Frequency Selective Surfaces Using Microlens Photolithography” M.-H. Wu, K. E. Paul, J. Yang, and G. M. Whitesides* Appl. Phys. Lett., 2002, 80, 3500-3502 [Link]
10. “Catalytic Oxidations of Steroid Substrates by Artificial Cytochrome P-450 Enzymes” J. Yang, B. Gabriele, S. Belvedere, Y. Huang and R. Breslow* J. Org. Chem., 2002, 67, 5057-5067 [Link]
9. “Facile Synthesis of b-Cyclodextrin Dithiols” J. Yang* and D. K. Leung Bioorg. & Med. Chem. Lett., 2002, 12, 169-170 [Link]
8. “Biomimetic Hydroxylation of Saturated Carbons with Artificial Cytochrome P-450 Enzymes—Liberating Chemistry from the Tyranny of Functional Groups” R. Breslow*, J. Yang, and J. Yan Tetrahedron, 2002, 58, 653-659 [Link]
1996-2000
7. “The hydroxylation and amidation of equilenin acetate catalyzed by chloro[5, 10, 15, 20-tetrakis(pentafluorophenyl)porphyrinato]manganese (III)” J. Yang, R. Weinberg, and R. Breslow* Chem. Comm., 2000, 531-532 [Link]
6. “Selective Hydroxylation of a Steroid at C-9 by an Artificial Cytochrome P-450” J. Yang and R. Breslow* Angew. Chem., 2000, 112, 2804-2806; Angew.. Chem., Int. Ed., 2000, 39, 2692-2695 [Link]
5. “Regioselective Oxidations of Equilenin Derivatives Catalyzed by a Rhodium (III) Porphyrin Complex- Contrast with the Manganese (III) Porphyrin” J. Yang and R. Breslow* Tet. Lett. 2000, 41, 8063-8067 [Link]
4. “Geometrically directed steroid hydroxylation with high turnover by a fluorinated cytochrome P-450” R. Breslow*, B. Gabriele, and J. Yang Tet. Lett. 1998, 39, 2887-2890 [Link]
3. “An artificial cytochrome P-450 that hydroxylates unactivated carbons with regio- and stereoselectivity and useful catalytic turnovers” R. Breslow*, Y. Huang, X. Zhang, and J. Yang Proc. Nat. Acad. Sci. USA, 1997, 94, 11156-11158 [Link]
2. “Spontaneous fission properties of 262Rf” M. R. Lane, K. E. Gregorich, D. M. Lee, M. F. Mohar, M. Hsu, C.D. Katcher, B. Kadkhodayan, M. P. Neu, N. J. Stoyer, E.R. Sylwester, J. C. Yang, D. C. Hoffman* Phys. Rev. C, 1996, 53 v.6, 2893-2899 [Link]
1. “Chemical studies of Rutherfordium (element 104). 2. Solvent extraction into tributylphosphate from HBr solutions” C. D. Katcher, K. E. Gregorich, D. M. Lee, Y. Watanabe, B. Kadkhodayan, B. Wierczinski, M. R. Lane, E. R. Sylwester, D. A. Keeney, M. Hendricks, N. J. Stoyer, J. Yang, M. Hsu, D. C. Hoffman*, A. Bilewicz Radiochimica Acta, 1996, 75:3, 127-133
Patents:
14. “Targeted Enediynes for Selective Degradation of Aggregated beta-Amyloid Peptides” J. Yang and M. Rubinshtein: Provisional Patent (07/2008)
13. “Novel Ion Channel-Forming Peptides” J. Yang, S. Blake, and M. Mayer: US Patent (07/2008)
12. “Screening Assays for Inhibitors of Amyloid-beta Peptide Ion Channel Formation” M. Mayer and J. Yang: US Patent (05/2008) 08/006,885
11. “Small Molecules that Target Aggrgated beta-Amyloid as Diagnostics and/or Therapeutics for Alzheimer’s Disease” J. Yang, P. Inbar, M.R. Bautista, and M. Mayer: US Patent (05/2008) 08/065,410
10. “Novel Ion Channel-Forming Peptides” J. Yang and S. Blake: Provisional Patent (07/2007) 60/948,689
9. “Screening Assays for Inhibitors of Amyloid-beta Peptide Ion Channel Formation” M. Mayer and J. Yang: Provisional Patent (05/2007) 60/932,293
8. “Compounds and Methods for the Diagnosis and Treatment of Alzheimer’s Disease” J. Yang, P. Inbar, M.R. Bautista, and M. Mayer: Provisional Patent (05/2007) 60/940,869
7. “New Acid-Sensitive Linkers for Drug Delivery” J. Yang, S.D. Kong, A. Luong, and S. B. Howell: US Patent (04/2007) 07/008,499
6. “Compounds and Methods for the Diagnosis and Treatment of Amyloid Associated Diseases” J. Yang and P. Inbar: US Patent (07/2006) 11/487,224
For more information visit the technology transfer office at: SD2005-261, SD2005-262 and SD2006-105
5. “New pH-Sensitive Linkers for Drug Delivery” J. Yang and S.D. Kong: Provisional Patent (04/2006) 60/789,014
4. “Compounds and Methods for the Diagnosis and Treatment of Alzheimer’s Disease” J. Yang and P. Inbar: Provisional Patent (12/2005): 60/699,726
3. “New approach for therapeutics for Alzheimer’s Disease” J. Yang, and P. Inbar: Provisional Patent (07/2005) 60/750,422
2. R. Breslow, J. Yang, and B. Gabriele: European Patent 99917373.5-2115 EP1084148
1. “Catalyst that oxidizes steroids and other substrates with catalytic turnover” R. Breslow, J. Yang, and B. Gabriele: U.S. Patent 6,103,892