NEBI-4

A pH-sensitive bifunctional N-Ethoxybenzylimidazole (NEBI) crosslinker enables conjugation of drugs to macromolecular drug delivery carriers.  These drugs are released in active form after internalization and localization of the carriers into acidic lysosomes of cells.

Recent Lab News:

Congrats to Dan, Kevin, and Jessica for defending their Ph.Ds!


Congratulations to Jessica for her paper on the reduction of amyloid-β associated cell toxicity and oxidative stress using benzothiazole amphiphiles, which has been accepted for publication in ACS Chem. Neurosci.! [Link]


Congratulations to Jessica for her paper on the effect of benzothiazole amphiphiles on dendritic spine density in primary neurons, which has been accepted for publication in J. Biol. Chem.! [Link]


Congratulations to Tak for his paper on the effect of cyclohexane rings on permeability in Archaea-inspired lipids, which has been accepted for publication in Angew. Chem., Int. Ed.! [Link]


Congratulations to Geoffray for developing a fluorescent probe for monitoring α-secretase in living cells, which was accepted for publication in ACS Chem. Neurosci.! [Link]


Congratulations to Dan for developing an amyloid-targeting nanoparticle for the inhibition of SEVI-mediated HIV infectivity, which was accepted for publication in ACS Nano! [Link]


Congratulations to Yuchen for her paper on the use of a pH-sensitive NEBI linker to deliver an indenoisoquinoline into cells via folate receptor uptake, which has been published in Bioconj. Chem.! [Link]


Congratulations to Kevin Cao for developing  a method to fluorescently discriminate between amyloid deposits associated with different neurological disorders in brain, which has been accepted for publication in the  J. Am. Chem. Soc.! [Link]


Congratulations to Christina for developing oligovalent amyloid-binding agents that show improved capability to reduce SEVI-mediated enhancement of HIV infection in cells, which has been published in the J. Am. Chem. Soc! [Link]


Congratulations to Christina for her development of a quantitative ELISA-based method to quantify small molecule-amyloid binding interactions, which has been published in Analytical Chemistry! [Link]


Congratulations to Lila for her discovery of potentially important pathological, intracellular interactions between amyloid peptides and proteins in Alzheimer’s disease, which has been accepted for publication in the Journal of Biological Chemistry! [Link]


See our recent paper on the use of amyloid-targeting small molecules to inhibit SEVI- and Semen-enhanced infection of HIV in immune cells published in the Journal of Biological Chemistry [Link]


Congratulations to Xiaobei for her discovery of the effect of Amyloid peptides on proteasome function published in ACS Chemical Neuroscience! [Link] (One of the top 10 most read articles in ACS Chemical Neuroscience in 2010 and one of the top 20 most cited articles in this journal!)


Congratulations to Alice for having her paper on pH-sensitive bifunctional crosslinkers accepted in Org. Biomol. Chem.! [Link]


Congratulations to Mark for having his paper on new methodology for synthesizing functionalized PLA-based polymers accepted in Org. Lett.! [Link]


See our recent comprehensive review on applications of nanopores in nanomedicine, sensing, and nanoelectronics in Curr. Opin. Biotechnol. [Link]


Congratulations to Mike for creating the world’s smallest fluidic diode! See his new paper in J. Am. Chem. Soc. [Link]


See our recent paper on the rational design of amyloid-binding agents in ChemMedChem [Link]